Surgical Healing and Burns

REGENERATIVE TREATMENT FOR SURGICAL HEALING AND BURNS IN LONDON

With a proven track record in regenerative medicine, you’re in safe hands.

Many people are left with scars as a result of surgery that they undergo in order to treat various health conditions. Whilst surgeons will always do their best to keep the impact of surgical wounds to a minimum, scarring can nonetheless be significant.

This has led to an increase in research into regenerative approaches that aim to achieve scar-free healing. The use of stem cells has shown promising results, including for the treatment of surgical and non-surgical injuries such as burns.

Stem cell treatment is a relatively new discipline of regenerative medicine. Where there is an established medical need, a clinician may now prescribe stem cell therapy as a treatment within the UK, in accordance with regulation by the Human Tissue Authority.

DR KHAN SAYS

Regenerative treatments are an option for people who may have already tried, or considered, conventional treatments. Research using stem cells with latest technology has shown promising results.

DR TEE SAYS

Stem cells are located throughout the body and act as natural healers. Studies suggest that when used for medical purposes, stem cells have the potential to accelerate tissue repair, stimulate tissue regeneration, and decrease inflammation.

SURGICAL HEALING AND STEM CELL RESEARCH

Scarring is the body’s mechanism for bridging a wound with a biological sticking plaster, which consists of connective tissue formed from hard collagen.  However, it is often an imperfect process and any cells suspended within scar tissue have little or no blood supply. Traditional methods to reduce scarring include skin grafts, pressure dressings, and topical creams and ointments.

However, stem cells have potential for wound healing due to their ability to multiply and change into other types of cells in order to stimulate tissue regeneration, settle inflammation, and increase the flow of blood and nutrients. A study published in 2015 stated: “Interest in wound healing research continues to grow, with much focus now directed towards stem cell therapies to overcome limitations in our current wound management practices.” [1]

Significant scarring such as hypertrophic scars, which are thickened and raised from the skin, may result in a loss of tissue function and can cause patients a great deal of distress. Keloid scars, which invade surrounding tissue, are also a concern.

Stem cells, and the growth factors that they produce, play a major role in the body’s ability to repair itself. Biological preparations such as stromal vascular fraction (SVF) and platelet rich plasma (PRP) can also be used for regenerative purposes.

These types of cellular materials can potentially be introduced to the site of a wound, sometimes alongside a fat transfer, to promote better healing. Fatty tissue is used because it is known to be a rich repository of repair cells.

WHAT ARE STEM CELLS?

Stem cells are special types of cell that occur naturally within the body. They have the ability to replicate themselves or develop into different types of cells through a process known as differentiation.

Hence stem cells have the potential to become new cells in order to perform specific functions. For example, they can differentiate to become blood cells or other types of cell that are active within the immune system. This process enables stem cells not only to play a unique role in the body’s ability to heal itself, but also to encourage the growth of healthy tissue.

HOW ARE STEM CELLS USED IN MEDICINE?

Whilst stem cell therapy is relatively new, stem cells have been the subject of over 40 years of research and there have been a large number of clinical trails.  A limited number of treatments for certain medical conditions are now available in the UK.

When used for medical purposes, research suggests stem cells can accelerate tissue repair, stimulate tissue regeneration, decrease inflammation, and stimulate new blood vessel growth.

WHAT TREATMENTS ARE THERE FOR BETTER HEALING

There are number of treatments for better healing, which which your doctor can advise you upon. These include topical creams, pressure dressings, or in some cases surgery or skin grafts.

However, those patients seeking alternatives to established approaches may be able to benefit from regenerative therapies such as stem cells, SVF or PRP, where appropriate.

Research published in 2014 stated: “Studies have demonstrated the possible role of several stem cells in wound healing. In particular, epidermal stem cells and mesenchymal stem cells have been implicated in wound repair and regeneration.” [2]

CAN I HAVE STEM CELL THERAPY?

Stem cell therapy may be considered for people who require an alternative approach to established procedures. It may be suitable for patients aged 18 to 75 or children in special circumstances, whose condition is stable enough to undergo treatment.

The first stage is to book a consultation with a qualified medical practitioner, who will assess your medical history in order to potentially make a pre-approval application. A multi-disciplinary panel of experts will then consider your application.

If you application is approved, you will then be invited undergo a full health screening and detailed tests to ensure stem cell treatment is an appropriate approach for you. Provided you pass the assessment criteria, you may then begin treatment.

WHAT DOES TREATMENT INVOLVE?

Patients generally require a preparation period that may involve a number of procedures to ensure your regenerative system is at its most receptive. The stem cells can typically then be injected into the body, which depending on the nature of your condition can either be done by intra-tissue injection.

WHERE DO THE STEM CELLS COME FROM?

The stem cells may be either ‘autologous’ or ‘allogeneic’. Autologous stem cells are processed after being harvested from tissue from the patient’s own body, whereas allogeneic stem cells are cultured in a laboratory from a donated source. In our clinics we only use ‘Autologous’ tissue- derived cells. ‘Allogeneic’ cells are currently used for research purposes, or by the NHS for bone marrow transplantation.

HOW ARE STEM CELLS REGULATED?

Stem cell therapies are classed as nouvelle treatments or ‘specials’, which are a permissible category of medicines that are available to meet the clinical needs of an individual patient.
The progress of stem cell patients is carefully monitored and the treating team have a regulatory duty to report any relevant findings to the responsible research NHS Body, with a view to stem cell therapy becoming a standardised licensed treatment in the future.

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ABOUT DR KHAN AND DR TEE

The Cellular & Regenerative practice in Harley Street was co-founded by Dr Aamer Khan, author of the forthcoming book, ‘Aesthetic Treatments in Regenerative Medicine:  Stem Cells, Stromal Vascular Fraction, Platelet Rich Plasma, and Platelet Rich Fibrin.’

Dr Aamer Khan

Qualifying as a Doctor at the University of Birmingham in 1986 with an MB ChB (Bachelor of Medicine, Bachelor of Surgery), Dr Khan completed his postgraduate training in University Hospitals Birmingham. He spent 24 years working within the NHS, including many years in General Practice in a community with the largest proportion of elderly population in the UK. This led to his passion to study cellular and regenerative medicine, and develop an integrative approach to his medical practice.
As part of his cellular and regenerative interest, Dr. Khan’s Clinic, was one of the first to work with Cytori Stem Cell Technologies in 2008. In 2010, he retired from the NHS to refine protocols at the Harley Street Skin Clinic, and develop his integrative medical practice and the Cellular + Regenerative clinic.

Dr Mike Tee

Dr Mike Tee MB, BChir, BSc (Hons), DLO, DRCOG, MRCGP, is a Cambridge medical graduate, and has over 25 years of experience in the medical profession. Dr Tee is well regarded as an expert in Dermal Fillers, PRP, Thread Lifts, Mole Removal & dermatological minor surgery. Dr. Tee has worked very closely with Dr. Khan and developed a wealth of knowledge and expertise in integrative and regenerative medicine.

SOURCES

1 – Michael S. Hu, Tripp Leavitt, Samir Malhotra, Dominik Duscher, Michael S. Pollhammer, Graham G. Walmsley, Zeshaan N. Maan, Alexander T. M. Cheung, Manfred Schmidt, Georg M. Huemer, Michael T. Longaker, H. Peter Lorenz, “Stem Cell-Based Therapeutics to Improve Wound Healing”, Plastic Surgery International, vol. 2015, Article ID 383581, 7 pages, 2015. https://doi.org/10.1155/2015/383581
https://www.hindawi.com/journals/psi/2015/383581/

2 – Hu MS, Rennert RC, McArdle A, et al. The Role of Stem Cells During Scarless Skin Wound Healing. Adv Wound Care (New Rochelle). 2014;3(4):304-314. doi:10.1089/wound.2013.0471
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985511/

NHS: Treatment – Scars
https://www.nhs.uk/conditions/scars/treatment/