Diabetes

REGENERATIVE TREATMENT FOR DIABETES IN LONDON

With a proven track record in regenerative medicine, you’re in safe hands.

Diabetes is a metabolic condition that causes a person’s blood sugar levels to fluctuate irregularly. It affects over 400 million people around the world, including 5 million people in the UK alone. Diabetes occurs when the body cannot make enough insulin, or can’t effectively utilise insulin in order to regulate glucose levels in the blood.

There are two main types of diabetes, Type 1 or Type 2, both of which when left untreated can result in damage to the nerves, eyes, kidneys and other major organs, including risk of heart attack.  Thankfully, there are a number of treatments available. These include insulin injections or drugs such as metformin, which can help to lower blood sugar.

Research suggests that stem cell therapies may also be able to play a positive role in the future treatment of diabetes. Stem cell treatment is a relatively new discipline of regenerative medicine. Where there is an established medical need, a clinician may now prescribe stem cell therapy as a treatment within the UK, in accordance with regulation by the Human Tissue Authority.

DR KHAN SAYS

“Regenerative treatments are an option for people who may have already tried, or considered, conventional treatments. Research using stem cells with latest technology has shown promising results.”

DR TEE SAYS

“Stem cells are located throughout the body and act as natural healers. Studies suggest that when used for medical purposes, stem cells have the potential to accelerate tissue repair, stimulate tissue regeneration, and decrease inflammation.”

DIABETES AND STEM CELL RESEARCH

When the body functions healthily, glucose in bloodstream can be stored in cells until it is needed for energy. However, people with diabetes are unable to process carbohydrates in the normal manner. Hence those affected by diabetes often spend their lives managing symptoms and carefully calculating their dietary requirements around the clock.

However, research in a number of countries, including in the UK and USA, suggests that stem cells may be able to play a role in treating Type 1 and Type 2 diabetes. For example, a study published in 2014 stated: “The recent progress in regenerative medicine, especially stem cell therapy, has suggested several novel and potential cures for T1D (Type 1 diabetes).”

When we are healthy, the body is able to process normal levels of glucose, which flows through the blood vessels. However, when the body is unable make use of insulin these levels increase and can result in a state called hyperglycemia.

Symptoms of hyperglycemia include excessive thirst, increased urination (particularly at night), blurred vision, and fatigue. Conversely, some medications for diabetes can cause low blood sugar, which is known as hypoglycemia. This can lead to sweating, tiredness, dizziness and trembling.

Diabetes occurs when insulin-producing beta cells are either destroyed by the immune system or do not function properly.  There are a number of clinical trials underway to evaluate how stem cells may be beneficial for diabetes. Research includes looking at ways to produce fully working beta cells from stem cells.

WHAT ARE STEM CELLS?

Stem cells are special types of cell that occur naturally within the body. They have the ability to replicate themselves or develop into different types of cells through a process known as differentiation.

Hence stem cells have the potential to become new cells in order to perform specific functions. For example, they can differentiate to become blood cells or other types of cell that are active within the immune system. This process enables stem cells not only to play a unique role in the body’s ability to heal itself, but also to encourage the growth of healthy tissue.

HOW ARE STEM CELLS USED IN MEDICINE?

Whilst stem cell therapy is relatively new, stem cells have been the subject of over 40 years of research and there have been a large number of clinical trails.  A limited number of treatments for certain medical conditions are now available in the UK.

When used for medical purposes, research suggests stem cells can accelerate tissue repair, stimulate tissue regeneration, decrease inflammation, and stimulate new blood vessel growth.

WHAT TREATMENTS ARE THERE FOR DIABETES?

There are a number of treatments to treat diabetes, which your doctor can advise you upon. Hence many people with diabetes are able to lead a good quality of life.

Type 1 diabetes can be treated via insulin injections or pumps.  Type 2 diabetes (which is the most common type) can be managed through healthy lifestyle choices (such as diet and exercise) and / or by using insulin or other medications.

However, research into the use of stem cells has also shown promising results for treating diabetes and further studies are underway.  Where there is an established medical need, it may be possible for certain diabetes patients to explore cellular options.

CAN I HAVE STEM CELL THERAPY?

Stem cell therapy may be considered for people who require an alternative approach to established procedures. It may be suitable for patients aged 18 to 75, or in special circumstances children, whose condition is stable enough to undergo treatment.

The first stage is to book a consultation with a qualified medical practitioner, who will assess your medical history in order to potentially make a pre-approval application. A multi-disciplinary panel of experts will then consider your application.

If you application is approved, you will then be invited undergo a full health screening and detailed tests to ensure stem cell treatment is an appropriate approach for you. Provided you pass the assessment criteria, you may then begin treatment.

WHAT DOES TREATMENT INVOLVE?

Patients generally require a preparation period that may involve a number of procedures to ensure your regenerative system is at its most receptive. The stem cells can typically then be injected into the body, which depending on the nature of your condition can either be done by intra-tissue injection.

WHERE DO THE STEM CELLS COME FROM?

The stem cells may be either ‘autologous’ or ‘allogeneic’. Autologous stem cells are processed after being harvested from tissue from the patient’s own body, whereas allogeneic stem cells are cultured in a laboratory from a donated source. In our clinics we only use ‘Autologous’ tissue- derived cells. ‘Allogeneic’ cells are currently used for research purposes, or by the NHS for bone marrow transplantation.

HOW ARE STEM CELLS REGULATED?

Stem cell therapies are classed as nouvelle treatments or ‘specials’, which are a permissible category of medicines that are available to meet the clinical needs of an individual patient.
The progress of stem cell patients is carefully monitored and the treating team have a regulatory duty to report any relevant findings to the responsible research NHS Body, with a view to stem cell therapy becoming a standardised licensed treatment in the future.

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About Dr Khan and Dr Tee

The Cellular & Regenerative practice in Harley Street was co-founded by Dr Aamer Khan, author of the forthcoming book, ‘Aesthetic Treatments in Regenerative Medicine: Stem Cells, Stromal Vascular Fraction, Platelet Rich Plasma, and Platelet Rich Fibrin.’

Dr Aamer Khan

Qualifying as a Doctor at the University of Birmingham in 1986 with an MB ChB (Bachelor of Medicine, Bachelor of Surgery), Dr Khan completed his postgraduate training in University Hospitals Birmingham. He spent 24 years working within the NHS, including many years in General Practice in a community with the largest proportion of elderly population in the UK. This led to his passion to study cellular and regenerative medicine, and develop an integrative approach to his medical practice.
As part of his cellular and regenerative interest, Dr. Khan’s Clinic, was one of the first to work with Cytori Stem Cell Technologies in 2008. In 2010, he retired from the NHS to refine protocols at the Harley Street Skin Clinic, and develop his integrative medical practice and the Cellular + Regenerative clinic.

Dr Mike Tee

Dr Mike Tee MB, BChir, BSc (Hons), DLO, DRCOG, MRCGP, is a Cambridge medical graduate, and has over 25 years of experience in the medical profession. Dr Tee is well regarded as an expert in Dermal Fillers, PRP, Thread Lifts, Mole Removal & dermatological minor surgery. Dr. Tee has worked very closely with Dr. Khan and developed a wealth of knowledge and expertise in integrative and regenerative medicine.

Sources

1 – Mesenchymal stem cell-based therapy for type 1 diabetes
[https://pubmed.ncbi.nlm.nih.gov/24641956/]

2 – Mesenchymal stem cell therapy in Type 2 diabetes mellitus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433043/

3 – Diabetes UK: Stem cells into beta cells
https://www.diabetes.org.uk/research/our-research-projects/london/stem-cells-into-beta-cells

Healthline: Everything you need to know about diabetes
https://www.healthline.com/health/diabetes#symptoms

NHS: Diabetes
https://www.nhs.uk/conditions/diabetes/