With a proven track record in regenerative medicine, you’re in safe hands.
Anyone who suffers from arthritis will know that the pain and discomfort that it causes may be unrelenting. Arthritis is a degenerative condition that affects the joints – including the fingers, wrists, knees, ankles, toes, and hips – often making even basic movement seem unbearable. The most common types of arthritis are osteoarthritis and rheumatoid arthritis.
There are a number of conventional treatment options available, including vitamin supplements, anti-inflammatory drugs, steroid injections, and surgery. Recent studies suggest that stem cell therapy may also be an alternative option for some patients.
Stem cell treatment is a relatively new discipline of regenerative medicine that research suggests can potentially improve joint function and reduce pain. Where there is an established medical need, a clinician may now prescribe stem cell therapy as a treatment within the UK, in accordance with regulation by the Human Tissue Authority.
“Regenerative treatments are an option for people who may have already tried, or considered, conventional treatments. Research using stem cells with latest technology has shown promising results.”
“Stem cells are located throughout the body and act as natural healers. Studies suggest that when used for medical purposes, stem cells have the potential to accelerate tissue repair, stimulate tissue regeneration, and decrease inflammation.”
More than 10 million people in the UK alone are affected by arthritis on a daily basis. It can impact anybody but is most common in women over 40, and those who have a genetic predisposition to the condition. It is caused by cartilage erosion and inflammation of the joints and surrounding connective tissue.
Research in a number of countries, including in the UK and USA, have shown that when stem cells are introduced into a part of the body damaged by arthritis, it may help to reduce pain and inflammation, and improve joint function. Hence for certain patients, stem cells may provide a non-surgical alternative for the treatment of arthritis.
Healthy joints rely on a matrix of connective tissues to facilitate movement, offer support and provide shock absorption. This requires healthy cartilage, tendons, and ligaments. Osteoarthritis is caused by ‘wear and tear’, resulting in stiffness and pain. Rheumatoid arthritis is an autoimmune disorder, in which the immune system attacks the joints, causing pain and inflammation.
Osteoarthritis (OA) results in gradual depletion of cartilage of the joint, along with tendons and ligaments, leading to the painful grating of the bones. A type of stem cell known as mesenchymal stem cells (MSCs) are known to play an important role in the body’s ability to regenerate. Studies have shown that MSCs therefore have great potential for the treatment of OA.
Rheumatoid arthritis (RA) causes the breakdown of bone and cartilage as well as excessive swelling of the synovium (the outer covering of the joint). This swelling can spread through the joint, causing severe inflammation. Research shows that mesenchymal stem cells have immunosuppressive capabilities, potentially making stem cell therapy a strong candidate for the treatment of RA.
Stem cells are special types of cell that occur naturally within the body. They have the ability to replicate themselves or develop into different types of cells through a process known as differentiation.
Hence stem cells have the potential to become new cells in order to perform specific functions. For example, they can differentiate to become blood cells or other types of cell that are active within the immune system. This process enables stem cells not only to play a unique role in the body’s ability to heal itself, but also to encourage the growth of healthy tissue.
Whilst stem cell therapy is relatively new, stem cells have been the subject of over 40 years of research and there have been a large number of clinical trails. A limited number of treatments for certain medical conditions are now available in the UK.
When used for medical purposes, research suggests stem cells can accelerate tissue repair, stimulate tissue regeneration, decrease inflammation, and stimulate new blood vessel growth.
There are number of effective treatments for arthritis, which your doctor can advise upon. Vitamins with anti-inflammatory properties can help with mild symptoms. Supplements include Vitamin D, Glucosamine* and Chondroitin Sulfate, Turmeric, and Omega 3.
More severe cases may require steroids or surgery. However, those patients seeking alternatives to surgery may choose stem cell therapies, where appropriate.
Stem cell research has shown promising results. For example, in 2020 a meta-analysis of stem cell therapy for osteoarthritis of the knee concluded that it “considerably reduces pain with no obvious additional side effects”.
* NOTE: Always seek medical advice before taking glucosamine,
which is derived from shellfish
Stem cell therapy may be considered for people who require an alternative approach to established procedures. It may be suitable for patients aged 18 to 75 or children in special circumstances, whose condition is stable enough to undergo treatment.
The first stage is to book a consultation with a qualified medical practitioner, who will assess your medical history in order to potentially make a pre-approval application. A multi-disciplinary panel of experts will then consider your application.
If you application is approved, you will then be invited undergo a full health screening and detailed tests to ensure stem cell treatment is an appropriate approach for you. Provided you pass the assessment criteria, you may then begin treatment.
Patients generally require a preparation period that may involve a number of procedures to ensure your regenerative system is at its most receptive. The stem cells can typically then be injected into the body, which depending on the nature of your condition can either be done by intra-tissue injection.
The stem cells may be either ‘autologous’ or ‘allogeneic’. Autologous stem cells are processed after being harvested from tissue from the patient’s own body, whereas allogeneic stem cells are cultured in a laboratory from a donated source. In our clinics we only use ‘Autologous’ tissue- derived cells. ‘Allogeneic’ cells are currently used for research purposes, or by the NHS for bone marrow transplantation.
Stem cell therapies are classed as nouvelle treatments or ‘specials’, which are a permissible category of medicines that are available to meet the clinical needs of an individual patient.
The progress of stem cell patients is carefully monitored and the treating team have a regulatory duty to report any relevant findings to the responsible research NHS Body, with a view to stem cell therapy becoming a standardised licensed treatment in the future.
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The Cellular & Regenerative practice in Harley Street was co-founded by Dr Aamer Khan, author of the forthcoming book, ‘Aesthetic Treatments in Regenerative Medicine: Stem Cells, Stromal Vascular Fraction, Platelet Rich Plasma, and Platelet Rich Fibrin.’
Qualifying as a Doctor at the University of Birmingham in 1986 with an MB ChB (Bachelor of Medicine, Bachelor of Surgery), Dr Khan completed his postgraduate training in University Hospitals Birmingham. He spent 24 years working within the NHS, including many years in General Practice in a community with the largest proportion of elderly population in the UK. This led to his passion to study cellular and regenerative medicine, and develop an integrative approach to his medical practice. As part of his cellular and regenerative interest, Dr. Khan’s Clinic, was one of the first to work with Cytori Stem Cell Technologies in 2008. In 2010, he retired from the NHS to refine protocols at the Harley Street Skin Clinic, and develop his integrative medical practice and the Cellular + Regenerative clinic.
Dr Mike Tee MB, BChir, BSc (Hons), DLO, DRCOG, MRCGP, is a Cambridge medical graduate and has over 25 years of experience in the medical profession. Dr Tee is well regarded as an expert in Dermal Fillers, PRP, Thread Lifts, Mole Removal & dermatological minor surgery. Dr. Tee has worked very closely with Dr. Khan and developed a wealth of knowledge and expertise in integrative and regenerative medicine.
Mesenchymal stem cells in knee osteoarthritis treatment:
A systematic review and meta-analysis
[https://pubmed.ncbi.nlm.nih.gov/32913710/]
Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression
by Controlling Memory T Cell Response
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477064/ ]
Mesenchymal stem cells – a promising strategy for
treating knee osteoarthritis
[https://online.boneandjoint.org.uk/doi/full/10.1302/2046-3758.910.BJR-2020-0031.R3 ]
Clinical efficacy and safety of stem cell therapy for knee osteoarthritis
[https://pubmed.ncbi.nlm.nih.gov/32176071/ ]