COPD

REGENERATIVE TREATMENT FOR COPD IN LONDON

With a proven track record in regenerative medicine, you’re in safe hands.

Chronic obstructive pulmonary disease (COPD) is a term used to describe a group of lung conditions that cause difficulty in breathing. Symptoms also may include a persistent chesty cough, often accompanied by phlegm, and frequent chest infections. The two most common forms of COPD are emphysema and bronchitis. COPD is usually progressive, hence it is likely to worsen if left untreated and may lead to significant lung damage.

COPD is usually diagnosed in patients aged in their 50s or older and is linked to factors such as smoking, exposure to fumes or dust, or genetic predisposition. Treatments include lifestyle changes, inhalers and drugs that make it easier to breathe, or in some cases surgery or lung transplant. Research suggests stem cell therapy may also be an option for certain patients with COPD.

Stem cell treatment is a relatively new discipline of regenerative medicine. Where there is an established medical need, a clinician may now prescribe stem cell therapy as a treatment within the UK, in accordance with regulation by the Human Tissue Authority.

DR KHAN SAYS

“Regenerative treatments are an option for people who may have already tried, or considered, conventional treatments. Research using stem cells with  latest technology has shown promising results.”

DR TEE SAYS

“Stem cells are located throughout the body and act as natural healers. Studies suggest that when used for medical purposes, stem cells have the potential to accelerate tissue repair, stimulate tissue regeneration, and decrease inflammation.”

STEM CELL RESEARCH AND COPD

Stem cells are known to possess unique biological properties, including the ability to self-renew. They can also change into different types of cell in order to perform specific functions with the body’s healing process and immune system. They can also issue instructions to other types of regenerative cells. These properties make stem cells of interest in the field of COPD research, which has resulted in a number of studies and clinical trials.

A study published in 2017 stated: “Stem cell based therapy offers a promising therapeutic approach that has shown potential in diverse degenerative lung diseases. Preclinical studies have demonstrated encouraging outcomes of mesenchymal stem/stromal cells (MSCs) therapy for lung disorders including emphysema, bronchopulmonary dysplasia, fibrosis, and acute respiratory distress syndrome.” [1]

It is estimated that that 3 million people in the UK alone have COPD, of whom 2 million remain undiagnosed. If the condition is spotted relatively early, it is often possible to slow any further decline in lung function through conventional treatment. Hence, improving a patient’s quality of life and enabling them to remain active. However, for many people COPD can continue to have a dramatic impact on their everyday life.

Many patients with COPD have both emphysema and bronchitis. Emphysema damages the small air sacs known as alveoli, which exist within the lungs. This reduces the amount of oxygen that can reach the bloodstream. Emphysema also reduces the surface area of the lungs and causes them to lose their elasticity, leading to shortness of breath, especially when exercising.

Bronchitis occurs when the airways of the respiratory system, known as the bronchi, become irritated and inflamed. It can be a temporary problem caused by an infection or a chronic condition that reoccurs and worsens over time. People with bronchitis may experience a hacking cough and the bringing up of mucus, along with wheezing and tightness of the chest.

WHAT ARE STEM CELLS?

Stem cells are special types of cell that occur naturally within the body. They have the ability to replicate themselves or develop into different types of cells through a process known as differentiation.

Hence stem cells have the potential to become new cells in order to perform specific functions. For example, they can differentiate to become blood cells or other types of cell that are active within the immune system. This process enables stem cells not only to play a unique role in the body’s ability to heal itself, but also to encourage the growth of healthy tissue.

HOW ARE STEM CELLS USED IN MEDICINE?

Whilst stem cell therapy is relatively new, stem cells have been the subject of over 40 years of research and there have been a large number of clinical trails.  A limited number of treatments for certain medical conditions are now available in the UK.

When used for medical purposes, research suggests stem cells can accelerate tissue repair, stimulate tissue regeneration, decrease inflammation, and stimulate new blood vessel growth.

WHAT TREATMENTS ARE AVAILABLE FOR COPD?

There are number of established treatments for COPD, which your doctor can advise you upon. These include inhalers that contain steroids and / or bronchodilators such as salbutamol in order to reduce inflammation. Patients may also be offered special exercise programmes and lifestyle advice, such as giving up smoking.

In severe cases, surgery may be recommended or even lung transplants for a small number of patients. However, recent advances in medical research suggest that stem therapy may also have potential to play a role in the treatment of COPD.

In particular, mesenchymal stem cells (MSCs) have the ability to regulate inflammation and boost tissue regeneration. Hence, research suggests that MSC therapy holds promise for the treatment of chronic lung diseases, especially when administered at an early stage.
[2]

CAN I HAVE STEM CELL THERAPY?

Stem cell therapy may be considered for people who require an alternative approach to established procedures. It may be suitable for patients aged 18 to 75 (or children in special circumstances) whose condition is stable enough to undergo treatment.

The first stage is to book a consultation with a qualified medical practitioner, who will assess your medical history in order to potentially make a pre-approval application. A multi-disciplinary panel of experts will then consider your application.

If you application is approved, you will then be invited undergo a full health screening and detailed tests to ensure stem cell treatment is an appropriate approach for you. Provided you pass the assessment criteria, you may then begin treatment.

WHAT DOES TREATMENT INVOLVE?

Patients generally require a preparation period that may involve a number of procedures to ensure your regenerative system is at its most receptive. The stem cells can typically then be injected into the body, which depending on the nature of your condition can either be done by intra-tissue injection.

WHERE DO THE STEM CELLS COME FROM?

The stem cells may be either ‘autologous’ or ‘allogeneic’. Autologous stem cells are processed after being harvested from tissue from the patient’s own body, whereas allogeneic stem cells are cultured in a laboratory from a donated source. In our clinics we only use ‘Autologous’ tissue- derived cells. ‘Allogeneic’ cells are currently used for research purposes, or by the NHS for bone marrow transplantation.

HOW ARE STEM CELLS REGULATED?

Stem cell therapies are classed as nouvelle treatments or ‘specials’, which are a permissible category of medicines that are available to meet the clinical needs of an individual patient.
The progress of stem cell patients is carefully monitored and the treating team have a regulatory duty to report any relevant findings to the responsible research NHS Body, with a view to stem cell therapy becoming a standardised licensed treatment in the future.

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About Dr Khan and Dr Tee

The Cellular & Regenerative practice in Harley Street was co-founded by Dr Aamer Khan, author of the forthcoming book, ‘Aesthetic Treatments in Regenerative Medicine: Stem Cells, Stromal Vascular Fraction, Platelet Rich Plasma, and Platelet Rich Fibrin.’

Dr Aamer Khan

Qualifying as a Doctor at the University of Birmingham in 1986 with an MB ChB (Bachelor of Medicine, Bachelor of Surgery), Dr Khan completed his postgraduate training in University Hospitals Birmingham. He spent 24 years working within the NHS, including many years in General Practice in a community with the largest proportion of elderly population in the UK. This led to his passion to study cellular and regenerative medicine, and develop an integrative approach to his medical practice.
As part of his cellular and regenerative interest, Dr. Khan’s Clinic, was one of the first to work with Cytori Stem Cell Technologies in 2008. In 2010, he retired from the NHS to refine protocols at the Harley Street Skin Clinic, and develop his integrative medical practice and the Cellular + Regenerative clinic.

Dr Mike Tee

Dr Mike Tee MB, BChir, BSc (Hons), DLO, DRCOG, MRCGP, is a Cambridge medical graduate, and has over 25 years of experience in the medical profession. Dr Tee is well regarded as an expert in Dermal Fillers, PRP, Thread Lifts, Mole Removal & dermatological minor surgery. Dr. Tee has worked very closely with Dr. Khan and developed a wealth of knowledge and expertise in integrative and regenerative medicine.

Sources

1 – Mesenchymal Stem Cell Administration in Patients with
Chronic Obstructive Pulmonary Disease: State of the Science
– STEM CELLS INTERNATIONAL
[https://doi.org/10.1155/2017/8916570]

2 – The potential of mesenchymal stem cell therapy
for chronic lung disease
[https://www.tandfonline.com/doi/full/10.1080/17476348.2020.1679628]

NHS: COPD Overview
https://www.nhs.uk/conditions/chronic-obstructive-pulmonary-disease-copd/
Healthline: About COPD
https://www.healthline.com/health/copd